Epha2 in cancer
WebMembrane-bound erythropoietin-producing hepatocellular receptor tyrosine kinase class A2 (EphA2) is overexpressed in breast, prostate, urinary bladder, skin, lung, ovary and brain cancers. Areas covered in this review: EphA2 overexpression in cancers, its signaling mechanisms and strategies to target its deregulation. WebErythropoietin-producing hepatocellular receptor A2 (EphA2) is upregulated in gastric cancer tissues and cells, which is accompanied by epithelial-mesenchymal transition …
Epha2 in cancer
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WebApr 20, 2024 · The EphA2 receptor has become a new promising therapeutic target for breast cancer treatment. A number of targeting strategies have been developed (Table 1). First, antibodies or peptides can mimic EphrinA1 to inhibit EphA2 functions. Second, small molecular inhibitors can inhibit its kinase activity. WebAug 18, 2024 · In particular, we focused on EphA2’s potential as a target for cancer treatment to provide insights into the application of EphA2 targeting in anticancer strategies. Overall, EphA2 represents a ...
WebEPHA2, for example, is upregulated in many cancers and its expression has been linked to increased malignancy and a poor clinical prognosis 27, 28, 31, 33. Furthermore, EPHA2 seems to be... WebJan 20, 2006 · In many cancers, high levels of EphA2 predict metastasis and poor survival ( 20, 22 – 24 ). Consistent with a suggested role in malignant behavior, overexpression of EphA2 has been reported to induce malignant transformation of a nontransformed cell line ( …
WebAug 18, 2024 · Overexpression and aggressive features of EphA2 in tumor cells and relatively low expression in most normal adult tissues make this protein a potential … WebThe EPH receptor A2 (EPHA2) gene is a member of the protein-tyrosine kinase subfamily of ephrin receptors and encodes a protein that associates with ephrin-A ligands. Missense …
Web[目的]探讨EphA2在结直肠癌细胞中的生物学功能及其信号调控机制.[方法]qRT-PCR法检测EphA2在结直肠癌细胞系中的表达情况,筛选得到表达量较高细胞株系,利用siRNA沉默该细胞系中EphA2的表达,利用MTT、Transwell、Western blot、qRT-PCR法检测细胞生物学功能变 …
WebThe EphA2 receptor is found at high levels in tumors and low levels in normal tissue and high EphA2 expression in biopsies is a predictor of poor outcome in patients. Drug discovery groups have therefore sought to develop EphA2-based therapies using small molecule, peptide, and nanoparticle-based approaches (1-3). breadth first search depth first searchWebEphrin type-A receptor 2 (EphA2) is overexpressed in multiple types of cancers such as breast, melanoma, ovarian adenocarcinoma. 11–13 Due to its strong association with tumor progression, metastasis, and prognosis, EphA2 is considered a possible therapeutic target, as well as a diagnostic and prognostic marker. cosmic runes osrs geWebThe EphA2 overexpression together with increased microvessel formation have been documented in primary colorectal human cancer specimens, suggesting a pro … cosmic self meaningWebJul 30, 2024 · In the study by Yoon et al. (2024) mentioned above, the effect of SAM domain linker (amino acids 901–929) mutations in conferring paclitaxel resistance in several cancer cell lines were attributed to the inability of mutated EphB6 to recruit the ubiquitin ligase c-Cbl to EphB6-EphA2 protein clusters. The inability to recruit c-Cbl by EphB6 ... cosmic runes runecrafting osrsWebMay 22, 2024 · In non-small cell lung cancer (NSCLC) cell lines, EphA2 is overexpressed in adherent cells. This ... cosmic seahorseWebEphA2 tyrosine kinase is upregulated in many cancers and correlated with poor survival of patients, including those with endometrial cancer. EphA2-targeted drugs have shown … breadth first search gfgWebIntroduction. Pancreatic cancer (PC) is one of the most lethal malignancies with a five-year survival rate of approximately 5%, and is the fourth leading cause of cancer-related … cosmic self storage