Grapefruit statin medication interaction

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August undefined, 2024

WebFor example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure. Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine.

Grapefruit Warning: It Can Interact with Common …

WebBackground: Simvastatin is a cholesterol-lowering agent that is metabolized through CYP3A4. We studied the effect of grapefruit juice on the pharmacokinetics of orally … WebSee the list of drugs that interact with Simvastatin. Includes information on severity of interaction and the level of evidence for it. ... Drug interaction information. ... Grapefruit juice increases the exposure to Simvastatin. Manufacturer advises avoid. Severity: cymh north shore

Full List of Drugs that Can Interact With Grapefruit Juice

WebApplies to: simvastatin. Grapefruit juice can significantly increase the blood levels of simvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death. WebAug 30, 2024 · 2. High cholesterol medications. Statins are a group of medications that treat high cholesterol. Some statins are more likely to interact with colchicine than others. These include simvastatin (Zocor, FloLipid), atorvastatin (Lipitor), and lovastatin. Fibrates are another group of medications that treat high cholesterol (and high triglycerides ... WebMay 8, 2024 · Grapefruit increases the blood levels of three common statins substantially, increasing the risk of rhabdomyolysis ( 4 ): Atorvastatin (Lipitor) Lovastatin (Mevacor) Simvastatin (Zocor) One... billy joel greatest hits iii

Common Grapefruit Juice Drug Interactions - Drugs.com

WebNov 6, 2024 · Don’t drink grapefruit juice if you’re taking any of these medications, unless advised to by your doctor: Some statins ( cholesterol-lowering drugs): lovastatin ( Mevacor ), atorvastatin ... WebAug 15, 2006 · Prominent medications known to interact with grapefruit include statins, antiarrhythmic agents, immunosuppressive agents, and calcium channel blockers. ... These alternative drugs may be ... billy joel greatest hits vinyl recordWebGrapefruit Juice and Statins We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. A daily glass of … billy joel greatest hits vol 1

"WebFeb 10, 2024 · In other words, the effects of statin drugs are increased in people who drink grapefruit juice. Adverse effects of statins include muscle and liver damage. Cytochrome P450 enzymes are stored in the endoplasmic reticulum of cells found not only in the liver but also in the kidneys, gastrointestinal tract, and lungs. " - Grapefruit statin medication interaction

Grapefruit statin medication interaction

The 9 Rosuvastatin (Crestor) Interactions to Avoid - GoodRx

WebGrapefruit can block an enzyme that helps your body break down certain medicines. If this enzyme is blocked, too much medication could remain and build up in your … WebFor example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and...

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WebMar 20, 2024 · Atorvastatin. Lovastatin. Simvastatin. One study showed that drinking a glass of grapefruit juice with simvastatin or lovastatin increased blood levels of these statins by 260% ( 5 ). Summary ... WebJun 11, 2024 · Drinking grapefruit juice while taking atorvastatin (Lipitor) or other "statins" might increase the effects and side effects of these medications. Grapefruit might interact with some "statins" including lovastatin ( Mevacor ), simvastatin ( Zocor ), and atorvastatin (Lipitor).

WebAug 4, 2024 · liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Common simvastatin side effects may include: headache; constipation, nausea, stomach pain; or. cold symptoms such as stuffy nose, sneezing, sore throat. WebDrug Interaction Studies. Simvastatin acid is a substrate of the transport protein OATP1B1. Concomitant administration of inhibitors of the transport protein OATP1B1 and/or CYP3A4 may lead to increased exposure of simvastatin acid. ... Table 4 displays the effect of coadministered drugs or grapefruit juice on simvastatin systemic exposure [see ...

WebGrapefruit has the following interaction information: Drug interaction information Severe interactions are highlighted with a red marker. Find out more about BNF interactions … WebJul 28, 2024 · Doctors warn against consuming Grapefruit juice if you take certain types of medication, such as statins, which are metabolized by the CYP3A4 enzyme. Grapefruit juice inhibits this enzyme so the liver produces less of it, and this affects the action of those drugs – they will be less effective. This is known as a drug interaction.

WebAug 26, 2024 · A common, well-known interaction is with grapefruit juice and statin medications — like atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Mevacor) — which are used to lower cholesterol. Grapefruit juice’s interactions are discussed more in detail in a previous GoodRx article .

WebOct 30, 2014 · In fact, it can help reverse a condition or reduce the need for medication. But even healthy foods, including fruits and vegetables, can cause unintended and possibly dangerous interactions with certain medications. Perhaps the best-known example is grapefruit, which, along with pomegranate, can alter the way certain cholesterol … billy joel greatest hits vol 1 2WebJul 22, 2014 · Grapefruit or grapefruit juice can interact with some, but certainly not all medications, prescribed for the following conditions or diseases: • Some blood-pressure-lowering medication • Some anti-anxiety medication • Some cholesterol-lowering medication • Some organ-transplant-rejection medication • Some anti-arrhythmia … cymh officesWebGrapefruit can block an enzyme that helps your body break down certain medicines. If this enzyme is blocked, too much medication could remain and build up in your bloodstream, causing too-high levels. Some of the medications whose metabolism can be affected by grapefruit include: atorvastatin, lovastatin and simvastatin (cholesterol-lowering drugs) cymh missionWebJun 26, 2024 · Interaction: Effect: Statins and Grapefruit juice Atorvastatin Simvastatin Lovastatin: Grapefruit juice contains furanocoumarins which interact with enzymes that reduce statin metabolism – increasing the risk of side effects such as muscle pain and aches.: Antiplatelet drugs Clopidogrel NSAIDs cymh new westminsterWebApr 3, 2024 · A. The pomelo (also called shaddock, pumelo, pommelo, and Chinese grapefruit) is the largest citrus fruit, ranging from the size of a cantaloupe to that of a … cymh office locationsWebSep 30, 2024 · Atorvastatin is a cholesterol-lowering medication that blocks the production of cholesterol. Learn about side effects, interactions and indications. ... (apart from grapefruit) interact with … billy joel greatest hits vol 3WebAug 11, 2024 · Zetia (ezetimibe) is a prescription drug used to treat certain types of high cholesterol in adults and children. Learn about side effects, dosage, and more. cymh maple ridge