Incidence of rhabdomyolysis with daptomycin

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August undefined, 2024

WebOct 5, 2024 · The primary outcome was overall incidence of creatine phosphokinase (CK) elevation, myopathy and rhabdomyolysis. Results and discussion A total of 74 patients who received daptomycin therapy were screened with 50 included in the study. WebNov 17, 2024 · However, the risk of developing rhabdomyolysis from statin therapy is very low, around 1.5 for each 100,000 people taking statins. Rhabdomyolysis or milder forms of muscle inflammation from statins can be diagnosed with a blood test measuring levels of …

Rhabdomyolysis Article - StatPearls

WebDaptomycin, a cyclic lipopeptide antibiotic, has bactericidal activity against Gram-positive organisms ... Although daptomycin causes unique adverse drug reactions such as elevation of creatine phosphokinase or rhabdomyolysis, the detailed ... and incidence of CPK elevation. Second, an in vitro pharmacological study was conducted using cul- WebRhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects were thought to be minimized by once-daily dosing. Prior elevations in serum CPK levels and/or myopathy have generally occurred at least 7 days after the initiation of therapy. flower delivery indian wells

Efficacy and Safety of Daptomycin in Patients with Renal

Webincidence of 2.8% in phase III clinical trials. CASE PRESENTATION: We report the case of 70 years old male patient ... Daptomycin induced rhabdomyolysis is a known possible complication and warrants high level of awareness due to life-threatening potential. … WebDaptomycin requires prior approval. Baseline CK followed by weekly CK should be measured in patients placed on daptomycin due to increased risk of rhabdomyolysis. Increased dose of daptomycin may be indicated with documented MRSA bacteremia. Infections due to … WebConclusion: Daptomycin can be associated with elevations in CPK level and rhabdomyolysis despite reduction of dose. A baseline CPK level before starting Daptomycin treatment and more frequent monitoring in patients with additional risks, including renal … greek sentence structure and matthew 10:20

(PDF) Rhabdomyolysis during Therapy with Daptomycin

WebDec 11, 2024 · Daptomycin is associated with an increased incidence of myopathy and rhabdomyolysis. There have been cases reported in patients with and without acute renal failure. Therefore weekly monitoring of creatine phosphokinase (CPK) levels is … WebThe incidence of rhabdomyolysis (defined as myopathy with a CK >40 times ULN) in patients on 80 mg/day was approximately 0.4% compared with 0% for patients on 20 mg/day. The incidence of myopathy, including rhabdomyolysis, was highest during the first year and then notably decreased during the subsequent years of treatment. ... 7.8 … flower delivery in dundeeWebMar 1, 2024 · irregular heartbeat. irritability. itching in the genital or other skin areas. itching, pain, redness, swelling, tenderness, or warmth on the skin. lightheadedness. loss of appetite. loss of consciousness. lower back or side pain. mood changes. greek septuagint online interlinear

"WebMar 7, 2024 · Int J Pharm 2024; 550:372. Parra-Ruiz J, Bravo-Molina A, Peña-Monje A, Hernández-Quero J. Activity of linezolid and high-dose daptomycin, alone or in combination, in an in vitro model of Staphylococcus aureus biofilm. J Antimicrob Chemother 2012; … " - Incidence of rhabdomyolysis with daptomycin

Incidence of rhabdomyolysis with daptomycin

WebOct 15, 2024 · Abstract. Background: Daptomycin-associated myopathy has been identified in 2%-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for daptomycin-associated myopathy are poorly defined, creatine phosphokinase (CPK) … WebMar 19, 2024 · The meta-analysis found that statin use significantly increased the incidence of DAP-related rhabdomyolysis compared with no statin use (6.2% vs 13.0%; odds ratio [OR] 3.83; 95% CI 1.43, 10.26) but had no significant effect on the incidence of DAP-related myopathy (6.6% vs 6.0%).

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Webclinically relevant adverse effects of daptomycin is reversible myopathy, especially when daptomycin is used in high doses. Here, we present a case of a patient with rhabdomyolysis preceded by hyperkalemia WebMay 18, 2024 · Daptomycin is the antibiotic most strongly associated with rhabdomyolysis, with rhabdomyolysis cases totaling 5.5% of daptomycin reports to FAERS, the FDA Adverse Event Reporting System. ... It has been suggested that decreased perioperative fluid administration may decrease the incidence of rhabdomyolysis in the bariatric surgery …

WebAug 1, 2024 · Its exact incidence is difficult to determine because of the lack of prospective studies and underreporting of many mild cases [3]. The disease appears more frequent amongst males, African-Americans, those aged <10 and >60 years old, and in persons with body mass index >40 kg/m 2 [4]. WebJun 1, 2014 · The incidence of rhabdomyolysis was significantly higher following concomitant daptomycin and statin use than with daptomycin alone (OR = 11.60, 95% CI 1.81-74.37, p=0.01, I2 =0%).

WebNov 10, 2024 · A typical adverse reaction of daptomycin is creatine phosphokinase (CPK) elevation, which occurred in 6.7% of patients in a phase 3 study [ 2 ]. This adverse reaction is dose-dependent, and Lai et al reported a significantly higher incidence of CPK elevation at doses of ≥8mg/kg than at <8mg/kg [ 3 ]. WebJul 1, 2006 · PDF The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III... Find, read and cite all the research you need ...

WebJun 15, 2006 · The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III clinical trials. Published case reports have documented the presence of myopathy in patients who received …

WebJan 16, 2024 · Rhabdomyolysis means dissolution of skeletal muscle, and it is characterized by leakage of muscle cell contents, myoglobin, sarcoplasmic proteins (creatine kinase, lactate dehydrogenase, aldolase, … flower delivery in bridgeport ct flower delivery in dickson tnWebDaptomycin is reported to cause an elevation in creatine kinase levels, although frank rhabdomyolysis is rare. An even more infrequent occurrence is the simultaneous development of acute kidney injury and drug-induced liver injury with rhabdomyolysis. Daptomycin and rifampin combination are used for synergistic bactericidal action against … flower delivery in durbanvilleWebApr 16, 2024 · Background: Daptomycin-associated myopathy has been identified in 2-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for daptomycin-associated myopathy are... flower delivery in durbanWebMar 7, 2024 · Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp [ 1,2 ]. greek services onlineWebDec 13, 2024 · Conclusion The combined use of daptomycin and statins were significant risk factors for the incidence of CPK elevation defined as levels ≥ULN or ≥5× ULN and rhabdomyolysis. COMPETING INTERESTS The authors declare that they do not have any … flower delivery in durango coWebof daptomycin use. Rhabdomyolysis is more commonly seen in a dose-dependent manner, especially at higher doses of daptomycin (8 mg/kg/day) compared to standard doses (6 mg/kg/day) [3]. Here, we described a case of recurrent hyperkalemia when daptomycin was initiated and completely resolved once daptomycin was discontinued. greek setting up family throuhg nesting