WebThe phenolphthiocerol molecules have either 35 or 37 carbon atoms. In most organisms the two hydroxyl groups of both phthiocerols and phenolphthiocerols are esterified by mycocerosic acids. In Mycobacterium marinum and Mycobacterium ulcerans, however, they are esterified by phthioceranic acids [ Daffe88, Daffe87 ]. About This Pathway WebMar 13, 2024 · National Center for Biotechnology Information

RCSB PDB - 7AKC: Structure of the of AcylTransferase domain of ...

WebThe resulting molecules or their diesters, the phenolphthiocerol dimycocerosates, would be then glycosylated and methylated by the same enzymes as those involved in the production of p -HBADs to yield the final PGL molecules ( 18 , 19 ). The origin of p -hydroxybenzoic acid (4-HB) in mycobacteria remains, however, to be established. WebThus, the phenolphthiocerol synthase PKS cluster of M. tuberculosis is responsible, in part, for the synthesis of a virulence determinant called phthiocerol dimycocerosate (PDIM). Here, we provide evidence that the PpsE protein, which is part of that cluster, interacts with the type II thioesterase TesA of M. tuberculosis. cef dje

MetaCyc phenolphthiocerol biosynthesis

WebNIOSH/OSHA. Up to 50 ppm: (APF = 10) Any air-purifying half-mask respirator with organic vapor cartridge (s) in combination with an N95, R95, or P95 filter. The following filters may … WebThe phenolphthiocerol molecules have either 35 or 37 carbon atoms. In most organisms the two hydroxyl groups of both phthiocerols and phenolphthiocerols are esterified by … WebDec 9, 2005 · Glycosylated p-hydroxybenzoic acid methyl esters and structurally related phenolphthiocerol glycolipids are important virulence factors of Mycobacterium tuberculosis. Although both types of molecules are thought to be derived from p-hydroxybenzoic acid, the origin of this putative biosynthetic precursor in mycobacteria … cef gravatai